Gene
cdt1
- ID
- ZDB-GENE-070111-1
- Name
- chromatin licensing and DNA replication factor 1
- Symbol
- cdt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA polymerase binding activity. Acts upstream of or within mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; mesoderm; proliferative region; pronephric duct; and somite. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158083 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 4 | Alliance | Meier-Gorlin syndrome 4 | 613804 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014939 | CDT1 Geminin-binding domain-like |
| Domain | IPR032054 | DNA replication factor Cdt1, C-terminal |
| Family | IPR045173 | DNA replication factor Cdt1 |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR038090 | DNA replication factor Cdt1, C-terminal WH domain superfamily |
Domain Details Per Protein
| Protein | Length | CDT1 Geminin-binding domain-like | DNA replication factor Cdt1 | DNA replication factor Cdt1, C-terminal | DNA replication factor Cdt1, C-terminal WH domain superfamily | Winged helix DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZJ1
|
628 | |||||
|
UniProtKB:E7F2R5
|
678 |
Interactions and Pathways
No data available
Plasmids
No data available