Gene
atoh8
- ID
- ZDB-GENE-061215-7
- Name
- atonal bHLH transcription factor 8
- Symbol
- atoh8 Nomenclature History
- Previous Names
-
- Zath6 (1)
- zgc:158314
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in heart looping and swim bladder formation. Acts upstream of or within heart development; regulation of neural retina development; and regulation of skeletal muscle cell differentiation. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; neural crest cell; optic cup; optic vesicle; and trunk. Orthologous to human ATOH8 (atonal bHLH transcription factor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1465 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-atoh8 | N/A | Yao et al., 2010 |
| MO2-atoh8 | N/A | Yao et al., 2010 |
| MO3-atoh8 | N/A | (2) |
| MO4-atoh8 | N/A | Rawnsley et al., 2013 |
| MO5-atoh8 | N/A | Rawnsley et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR032660 | Transcription factor ATOH8, basic helix-loop-helix domain |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription factor ATOH8, basic helix-loop-helix domain |
|---|---|---|---|---|---|---|
| UniProtKB:D2CLZ9 | InterPro | 266 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-10O22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158314 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079991 (1) | 2061 nt | ||
| Genomic | GenBank:BX284636 (1) | 171311 nt | ||
| Polypeptide | UniProtKB:D2CLZ9 (1) | 266 aa |
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Fragale, N., Divvela, S.S.K., Brand-Saberi, B. (2021) atoh8 expression pattern in early zebrafish embryonic development. Histochemistry and cell biology. 156(3):209-226
- Place, E.S., Smith, J.C. (2017) Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes. PLoS One. 12:e0171143
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Fang, F., Wasserman, S.M., Torres-Vazquez, J., Weinstein, B., Cao, F., Li, Z., Wilson, K.D., Yue, W., Wu, J.C., Xie, X., and Pei, X. (2014) The role of Hath6, a novel shear stress-responsive transcription factor, in endothelial differentiation and function modulation. Journal of Cell Science. 127(Pt 7):1428-40
- Huang, L., Zuo, Z., Zhang, Y., Wu, M., Lin, J.J., Wang, C. (2014) Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: Ocular developmental toxicity. Chemosphere. 108:55-61
- Flasse, L.C., Pirson, J.L., Stern, D.G., Von Berg, V., Manfroid, I., Peers, B., and Voz, M.L. (2013) Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biology. 11(1):78
- Rawnsley, D.R., Xiao, J., Lee, J.S., Liu, X., Mericko-Ishizuka, P., Kumar, V., He, J., Basu, A., Lu, M., Lynn, F.C., Pack, M., Gasa, R., Kahn, M.L. (2013) The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. The Journal of biological chemistry. 288:24429-40
- Yao, J., Zhou, J., Liu, Q., Lu, D., Wang, L., Qiao, X., and Jia, W. (2010) Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish. PLoS One. 5(6):e10945
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