Gene
tsfm
- ID
- ZDB-GENE-061215-17
- Name
- Ts translation elongation factor, mitochondrial
- Symbol
- tsfm Nomenclature History
- Previous Names
-
- zgc:158429 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within translational elongation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20767 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 3 | Alliance | Combined oxidative phosphorylation deficiency 3 | 610505 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018101 | Translation elongation factor Ts, conserved site |
| Domain | IPR014039 | Translation elongation factor EFTs/EF1B, dimerisation |
| Family | IPR001816 | Translation elongation factor EFTs/EF1B |
| Homologous_superfamily | IPR009060 | UBA-like superfamily |
| Homologous_superfamily | IPR036402 | Elongation factor Ts, dimerisation domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Elongation factor Ts, dimerisation domain superfamily | Translation elongation factor EFTs/EF1B | Translation elongation factor EFTs/EF1B, dimerisation | Translation elongation factor Ts, conserved site | UBA-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A1A5Z3 | InterPro | 305 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-74L3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158429 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080035 (1) | 1690 nt | ||
| Genomic | GenBank:BX548005 (1) | 218236 nt | ||
| Polypeptide | UniProtKB:A1A5Z3 (1) | 305 aa |
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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