Gene
nod2
- ID
- ZDB-GENE-061108-4
- Name
- nucleotide-binding oligomerization domain containing 2
- Symbol
- nod2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable CARD domain binding activity. Acts upstream of with a positive effect on regulation of canonical NF-kappaB signal transduction and regulation of gene expression. Acts upstream of or within defense response to bacterium; defense response to virus; and regulation of DNA-templated transcription. Located in cytoplasm. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nayar et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029339Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn68 | Allele with one deletion | Unknown | Unknown | TALEN | |
| mss13 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
| sa10156 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18880 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21011 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nod2 | (2) | |
| MO1-nod2 | N/A | Oehlers et al., 2011 |
| MO2-nod2 | N/A | Nie et al., 2017 |
| TALEN1-nod2 | Lee et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Blau syndrome | Alliance | Blau syndrome | 186580 |
| inflammatory bowel disease 1 | Alliance | {Inflammatory bowel disease 1, Crohn disease} | 266600 |
| {Yao syndrome} | 617321 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR041075 | NOD1/2, winged helix domain |
| Domain | IPR041267 | NACHT, LRR and PYD domains-containing protein, helical domain HD2 |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | CARD domain | Death-like domain superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NOD1/2, winged helix domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W3K2
|
980 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-91I12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328044 (1) | 4561 nt | ||
| Genomic | GenBank:CU929130 (1) | 32076 nt | ||
| Polypeptide | UniProtKB:F8W3K2 (1) | 980 aa |
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
- Novichkova, E., Nayak, S., Boussiba, S., Gopas, J., Zilberg, D., Khozin-Goldberg, I. (2023) Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD. Molecular Nutrition & Food Research. 67(6):e2200253
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Huang, X., Ai, F., Ji, C., Tu, P., Gao, Y., Wu, Y., Yan, F., Yu, T. (2021) A Rapid Screening Method of Candidate Probiotics for Inflammatory Bowel Diseases and the Anti-inflammatory Effect of the Selected Strain Bacillus smithii XY1. Frontiers in microbiology. 12:760385
- Nayar, S., Morrison, J.K., Giri, M., Gettler, K., Chuang, L.S., Walker, L.A., Ko, H.M., Kenigsberg, E., Kugathasan, S., Merad, M., Chu, J., Cho, J.H. (2021) A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease. Nature. 593(7858):275-281
- Chang, M.X., Xiong, F., Wu, X.M., Hu, Y.W. (2020) The expanding and function of NLRC3 or NLRC3-like in teleost fish: recent advances and novel insights. Developmental and comparative immunology. 114:103859
- Fang, H., Wu, X.M., Hu, Y.W., Song, Y.J., Zhang, J., Chang, M.X. (2020) NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Developmental and comparative immunology. 112:103769
- Mai, Y., Peng, S., Li, H., Gao, Y., Lai, Z. (2020) NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 240:108935
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