ZFIN is now using GRCz12tu for Genomic Data
Gene
nod2
- ID
- ZDB-GENE-061108-4
- Name
- nucleotide-binding oligomerization domain containing 2
- Symbol
- nod2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable CARD domain binding activity and pattern recognition receptor activity. Acts upstream of or within defense response to bacterium; defense response to virus; and regulation of DNA-templated transcription. Located in cytoplasm. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nayar et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Blau syndrome | Alliance | Blau syndrome | 186580 |
| inflammatory bowel disease 1 | Alliance | {Inflammatory bowel disease 1, Crohn disease} | 266600 |
| {Yao syndrome} | 617321 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers