Gene

cyld

ID
ZDB-GENE-061108-2
Name
cylindromatosis (turban tumor syndrome)
Symbol
cyld Nomenclature History
Previous Names
  • cyld
  • cylda (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables K63-linked deubiquitinase activity. Acts upstream of or within several processes, including central nervous system morphogenesis; protein linear deubiquitination; and regulation of embryonic development. Predicted to be located in several cellular components, including microtubule cytoskeleton; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; liver; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
Genome Resources
Note
3-Apr-2024 Examination of current data suggests this gene existed prior to the divergence of ray- and lobe-finned fishes; therefore, should not have a/b nomenclature
Comparative Information
Expression
All Expression Data
2 figures from Li et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyld Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brooke-Spiegler syndrome Alliance Brooke-Spiegler syndrome 605041
Cylindromatosis, familial 132700
Trichoepithelioma, multiple familial, 1 601606
?Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 619132
1 - 4 of 4
Associated With cyld Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR000938 CAP Gly-rich domain
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Homologous_superfamily IPR036859 CAP Gly-rich domain superfamily
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length CAP Gly-rich domain CAP Gly-rich domain superfamily Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Ubiquitin specific protease, conserved site
UniProtKB:E7FEV5 InterPro PDB 951
UniProtKB:F8W5E2 InterPro 912
UniProtKB:A0AB32TW17 InterPro 780
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cylda-201 (1)
Ensembl
Ensembl 4,522 nt
ZFIN BLAST
mRNA cylda-202 (1)
Ensembl
Ensembl 3,772 nt
ZFIN BLAST
mRNA cylda-203 (1)
Ensembl
Ensembl 3,024 nt
ZFIN BLAST
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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