Gene
cyld
- ID
- ZDB-GENE-061108-2
- Name
- cylindromatosis (turban tumor syndrome)
- Symbol
- cyld Nomenclature History
- Previous Names
-
- cyld
- cylda (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables K63-linked deubiquitinase activity. Acts upstream of or within several processes, including central nervous system morphogenesis; protein linear deubiquitination; and regulation of embryonic development. Predicted to be located in several cellular components, including microtubule cytoskeleton; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; liver; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
- Genome Resources
- Note
-
3-Apr-2024 Examination of current data suggests this gene existed prior to the divergence of ray- and lobe-finned fishes; therefore, should not have a/b nomenclature
- Comparative Information
-
- All Expression Data
- 2 figures from Li et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR000938 | CAP Gly-rich domain |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Homologous_superfamily | IPR036859 | CAP Gly-rich domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FEV5 | InterPro PDB | 951 | ||||||
| UniProtKB:F8W5E2 | InterPro | 912 | ||||||
| UniProtKB:A0AB32TW17 | InterPro | 780 |
Interactions and Pathways
No data available
Plasmids
No data available