Gene
fto
- ID
- ZDB-GENE-061108-1
- Name
- FTO alpha-ketoglutarate dependent dioxygenase
- Symbol
- fto Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable broad specificity oxidative DNA demethylase activity; ferrous iron binding activity; and mRNA N6-methyladenosine dioxygenase activity. Acts upstream of or within several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Osborn et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| e37 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| gyf7 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| gyf8 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| sa12749 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34123 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fto | Zebrafish Nomenclature Committee | |
| MO1-fto | N/A | Osborn et al., 2014 |
| MO2-fto | N/A | Osborn et al., 2014 |
| MO3-fto | N/A | O'Hare et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024366 | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal |
| Domain | IPR024367 | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain |
| Family | IPR032868 | Alpha-ketoglutarate-dependent dioxygenase FTO |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
| Homologous_superfamily | IPR038413 | FTO, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Alpha-ketoglutarate-dependent dioxygenase FTO | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal | FTO, C-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PZX3 | InterPro | 579 | |||||
| UniProtKB:A0A8M9PKY4 | InterPro | 580 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fto | monoclonal | IgG | Mouse |
|
PhosphoSolutions
|
1 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-20D12 | ZFIN Curated Data | |
| Contained in | BAC | CH73-34P21 | ZFIN Curated Data | |
| Contained in | BAC | CH73-104M21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-153H7 | ZFIN Curated Data | |
| Contained in | BAC | RP71-23N3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009303351 (1) | 3405 nt | ||
| Genomic | GenBank:CT030037 (1) | 203577 nt | ||
| Polypeptide | UniProtKB:A0A8M9PKY4 (1) | 580 aa |
- Chen, X., Wang, Y., Wang, J.N., Zhang, Y.C., Zhang, Y.R., Sun, R.X., Qin, B., Dai, Y.X., Zhu, H.J., Zhao, J.X., Zhang, W.W., Ji, J.D., Yuan, S.T., Shen, Q.D., Liu, Q.H. (2024) Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. EMBO Molecular Medicine. 16(2):294-318
- Sun, L., Ling, Y., Jiang, J., Wang, D., Wang, J., Li, J., Wang, X., Wang, H. (2020) Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq. Chemosphere. 251:126318
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sun, Q., Liu, X., Gong, B., Wu, D., Meng, A., Jia, S. (2017) Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. International journal of biological sciences. 13:1051-1066
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72
- Osborn, D.P., Roccasecca, R.M., McMurray, F., Hernandez-Hernandez, V., Mukherjee, S., Barroso, I., Stemple, D., Cox, R., Beales, P.L., and Christou-Savina, S. (2014) Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. PLoS One. 9(2):e87662
- Smemo, S., Tena, J.J., Kim, K.H., Gamazon, E.R., Sakabe, N.J., Gómez-Marín, C., Aneas, I., Credidio, F.L., Sobreira, D.R., Wasserman, N.F., Lee, J.H., Puviindran, V., Tam, D., Shen, M., Son, J.E., Vakili, N.A., Sung, H.K., Naranjo, S., Acemel, R.D., Manzanares, M., Nagy, A., Cox, N.J., Hui, C.C., Gómez-Skarmeta, J.L., Nóbrega, M.A. (2014) Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 507:371-5
- Xing, J., Jing, W., and Jiang, Y. (2013) Molecular characterization and expression analysis of fat mass and obesity-associated gene in rabbit. Journal of genetics. 92(3):481-488
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