Gene

fto

ID

ZDB-GENE-061108-1

Name

FTO alpha-ketoglutarate dependent dioxygenase

Symbol

fto Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Acts upstream of or within several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Osborn et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fto Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Growth retardation, developmental delay, facial dysmorphism	612938
		{Obesity, susceptibility to, BMIQ14}	612460

Associated With fto Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024366	Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Domain	IPR024367	Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
Family	IPR032868	Alpha-ketoglutarate-dependent dioxygenase FTO
Homologous_superfamily	IPR037151	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Homologous_superfamily	IPR038413	FTO, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily	Alpha-ketoglutarate-dependent dioxygenase FTO	Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain	Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal	FTO, C-terminal domain superfamily
UniProtKB:A0A8M1PZX3 InterPro	579
UniProtKB:A0A8M9PKY4 InterPro	580

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fto-201 (1) Ensembl	Ensembl	851 nt	Select Tool ZFIN BLAST
mRNA	fto-202 (1) Ensembl	Ensembl	3,353 nt	Select Tool ZFIN BLAST
mRNA	fto-203 (1) Ensembl	Ensembl	4,295 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fto	monoclonal	fto	IgG	Mouse	WB	PhosphoSolutions	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations