Gene
myh7l
- ID
- ZDB-GENE-061027-393
- Name
- myosin heavy chain 7-like
- Symbol
- myh7l Nomenclature History
- Previous Names
-
- myh1 (1)
- vmhcl
- zgc:113832
- zgc:152732
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within cardiac ventricle development and regulation of cardiac muscle hypertrophy. Predicted to be located in sarcomere. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in adaxial cell; cardiovascular system; and myotome. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113832 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Bu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A7E2H1
|
438 | |||||||
|
UniProtKB:Q4V9D2
|
638 | |||||||
|
UniProtKB:A0A8M1NBP6
|
1936 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
myh7l-207
(1)
|
Ensembl | 661 nt | ||
| mRNA |
myh7l-201
(1)
|
Ensembl | 826 nt | ||
| mRNA |
myh7l-203
(1)
|
Ensembl | 6,016 nt | ||
| mRNA |
myh7l-205
(1)
|
Ensembl | 686 nt | ||
| mRNA |
myh7l-208
(1)
|
Ensembl | 6,211 nt | ||
| mRNA |
myh7l-209
(1)
|
Ensembl | 6,292 nt | ||
| ncRNA |
vmhcl-003
(1)
|
Ensembl | 795 nt | ||
| ncRNA |
vmhcl-006
(1)
|
Ensembl | 460 nt | ||
| ncRNA |
vmhcl-007
(1)
|
Ensembl | 579 nt |
Interactions and Pathways
No data available
Plasmids
No data available