Gene

ppm1h

ID

ZDB-GENE-061027-190

Name

protein phosphatase, Mg2+/Mn2+ dependent, 1H

Symbol

ppm1h Nomenclature History

Previous Names

zgc:153678

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have [pyruvate dehydrogenase (lipoamide)] phosphatase activity and magnesium-dependent protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of pyruvate dehydrogenase activity. Predicted to localize to mitochondrion and nucleus. Is expressed in female organism. Orthologous to several human genes including PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Newman et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppm1h Human Ortholog

No data available

Associated With ppm1h Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001932	PPM-type phosphatase-like domain
Family	IPR015655	Protein phosphatase 2C
Homologous_superfamily	IPR036457	PPM-type phosphatase-like domain superfamily