ZFIN is now using GRCz12tu for Genomic Data
Gene

smg1

ID
ZDB-GENE-061013-767
Name
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Symbol
smg1 Nomenclature History
Previous Names
  • zgc:152973
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smg1 Human Ortholog
No data available
Associated With smg1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003152 FATC domain
Domain IPR014009 PIK-related kinase
Domain IPR035175 Serine/threonine-protein kinase SMG1, N-terminal
Domain IPR039414 SMG1, PIKK catalytic domain
Family IPR031559 Serine/threonine-protein kinase SMG1
Family IPR050517 DNA Damage Response and Repair Kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Domain Details Per Protein
Protein Additional Resources Length Armadillo-type fold DNA Damage Response and Repair Kinase FATC domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase Protein kinase-like domain superfamily Serine/threonine-protein kinase SMG1 Serine/threonine-protein kinase SMG1, N-terminal SMG1, PIKK catalytic domain
UniProtKB:A0A8I7UD82 InterPro
UniProtKB:F1QLT4 InterPro 3635
UniProtKB:C5J7W8 InterPro 3640
UniProtKB:A0A2R8QK29 InterPro 3644
UniProtKB:A0A8M3AQW2 InterPro 3641
UniProtKB:A0A8M3B0Y6 InterPro 3640
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA smg1-201 (1)
Ensembl
Ensembl 12,200 nt
ZFIN BLAST
mRNA smg1-202 (1)
Ensembl
Ensembl 12,274 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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