Gene
snai3
- ID
- ZDB-GENE-061013-757
- Name
- snail family zinc finger 3
- Symbol
- snai3 Nomenclature History
- Previous Names
-
- zgc:153535
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in notochord and somite. Orthologous to human SNAI3 (snail family transcriptional repressor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Snail/Krueppel C2H2-type Zinc-finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q08BJ5 | InterPro | 283 | |||
| UniProtKB:A0AB32TU81 | InterPro | 256 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-206I14 | Manzanares et al., 2004 | |
| Encodes | cDNA | MGC:153535 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192638 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077385 (1) | 1377 nt | ||
| Genomic | GenBank:BX088687 (2) | 107480 nt | ||
| Polypeptide | UniProtKB:Q08BJ5 (1) | 283 aa |
- Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Saran, N.K., Ramachandran, R. (2020) Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 23:100817
- Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Ramachandran, R. (2019) Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life science alliance. 2(5):
- Bickers, C., Española, S.D., Grainger, S., Pouget, C., Traver, D. (2018) Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 13:e0202747
- Lei, L., Yan, S.Y., Yang, R., Chen, J.Y., Li, Y., Bu, Y., Chang, N., Zhou, Q., Zhu, X., Li, C.Y., Xiong, J.W. (2017) Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors. Nucleic acids research. 45(6):3422-3436
- Taylor, K.M., Muraina, I., Brethour, D., Schmitt-Ulms, G., Nimmanon, T., Ziliotto, S., Kille, P., Hogstrand, C. (2016) Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. The Biochemical journal. 473(16):2531-44
- Lee, H.C., Lo, H.C., Lo, D.M., Su, M.Y., Hu, J.R., Wu, C.C., Chang, S.N., Dai, M.S., Tsai, C.T., Tsai, H.J. (2015) Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos. PLoS One. 10:e0144751
- Chen, C.H., Lin, D.S., Cheng, C.W., Lin, C.J., Lo, Y.K., Yen, C.C., Lee, A.Y., Hsiao, C.D. (2014) Cdc6 cooperates with c-Myc to promote genome instability and EMT in zebrafish. Oncotarget. 5(15):6300-11
- Liedtke, D., Erhard, I., and Schartl, M. (2011) snail gene expression in the medaka, Oryzias latipes. Gene expression patterns : GEP. 11(3-4):181-189
- Reischauer, S., Levesque, M.P., Nüsslein-Volhard, C., and Sonawane, M. (2009) Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genetics. 5(11):e1000720
- Manzanares, M., Blanco, M.J., and Nieto, M.A. (2004) Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Development genes and evolution. 214(1):47-53
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