Gene
tfam
- ID
- ZDB-GENE-061013-552
- Name
- transcription factor A, mitochondrial
- Symbol
- tfam Nomenclature History
- Previous Names
-
- zgc:153358
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Is expressed in brain; heart; heart tube; myotome; and pharyngeal arch 3-7. Orthologous to human TFAM (transcription factor A, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Ullah et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 15 | Alliance | ?Mitochondrial DNA depletion syndrome 15 (hepatocerebral type) | 617156 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) |
|---|---|---|---|---|
|
UniProtKB:Q08BL2
|
277 |
Interactions and Pathways
No data available
Plasmids
No data available