Gene
clcn4
- ID
- ZDB-GENE-061013-353
- Name
- chloride channel, voltage-sensitive 4
- Symbol
- clcn4 Nomenclature History
- Previous Names
-
- zgc:153764
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have chloride ion binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to Golgi apparatus; cytoplasmic vesicle; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Is expressed in brain; eye; gill; heart; and immune system. Orthologous to human CLCN4 (chloride voltage-gated channel 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Raynaud-Claes syndrome | Alliance | Raynaud-Claes syndrome | 300114 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CBS domain | CBS domain superfamily | Chloride channel ClC-4 | Chloride channel, core | Chloride channel, voltage gated |
|---|---|---|---|---|---|---|
|
UniProtKB:Q08BG8
|
768 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available