Gene
il1rapl1a
- ID
- ZDB-GENE-061013-249
- Name
- interleukin 1 receptor accessory protein-like 1a
- Symbol
- il1rapl1a Nomenclature History
- Previous Names
-
- fi18g04
- wu:fi18g04
- zgc:152866 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have interleukin-1 receptor activity. Predicted to be involved in negative regulation of exocytosis. Predicted to localize to cytoplasm; integral component of membrane; and plasma membrane. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Is expressed in optic tectum and telencephalon. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yoshida et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 21 | Alliance | Intellectual developmental disorder, X-linked 21 | 300143 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Domain | IPR000477 | Reverse transcriptase domain |
| Domain | IPR001584 | Integrase, catalytic core |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR041577 | Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain |
| Domain | IPR041588 | Integrase zinc-binding domain |
| Family | IPR004074 | Interleukin-1 receptor type I/II |
| Family | IPR015621 | Interleukin-1 receptor family |
| Family | IPR050951 | Retrovirus-related Pol polyprotein |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR043128 | Reverse transcriptase/Diguanylate cyclase domain |
| Homologous_superfamily | IPR043502 | DNA/RNA polymerase superfamily |
Domain Details Per Protein
| Protein | Length | Aspartic peptidase domain superfamily | DNA/RNA polymerase superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Integrase, catalytic core | Integrase zinc-binding domain | Interleukin-1 receptor family | Interleukin-1 receptor type I/II | Retrovirus-related Pol polyprotein | Reverse transcriptase/Diguanylate cyclase domain | Reverse transcriptase domain | Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q4P6
|
716 | |||||||||||||||||||
|
UniProtKB:A0A8M9QJT0
|
1520 | |||||||||||||||||||
|
UniProtKB:E9QD35
|
744 | |||||||||||||||||||
|
UniProtKB:B6ZK76
|
701 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
il1rapl1a-201
(1)
|
Ensembl | 4,080 nt | ||
| mRNA |
il1rapl1a-202
(1)
|
Ensembl | 1,647 nt |
Interactions and Pathways
No data available
Plasmids
No data available