Gene

grm3

ID

ZDB-GENE-061009-13

Name

glutamate receptor, metabotropic 3

Symbol

grm3 Nomenclature History

Previous Names

si:ch211-233h19.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have group II metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to localize to integral component of plasma membrane. Is expressed in brain and retinal neural layer. Orthologous to human GRM3 (glutamate metabotropic receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grm3 Human Ortholog

No data available

Associated With grm3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017979	GPCR, family 3, conserved site
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR011500	GPCR, family 3, nine cysteines domain
Domain	IPR017978	GPCR family 3, C-terminal
Family	IPR000162	GPCR, family 3, metabotropic glutamate receptor
Family	IPR000337	GPCR, family 3
Family	IPR001234	GPCR, family 3, metabotropic glutamate receptor 3
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR038550	GPCR, family 3, nine cysteines domain superfamily