Gene
slc18a3a
- ID
- ZDB-GENE-060929-990
- Name
- solute carrier family 18 member 3a
- Symbol
- slc18a3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable acetylcholine transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission. Predicted to act upstream of or within transmembrane transport and xenobiotic transport. Predicted to be located in membrane. Predicted to be part of AP-1 adaptor complex and AP-2 adaptor complex. Predicted to be active in terminal bouton. Is expressed in brain; retina; spinal cord; and spinal cord neural tube. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myasthenic syndrome 21 | Alliance | Myasthenic syndrome, congenital, 21, presynaptic | 617239 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | Major Facilitator Superfamily Vesicular Transporter | MFS transporter superfamily | Multidrug resistance protein |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q08C75 | InterPro | 513 | |||||
| UniProtKB:B2GS60 | InterPro | 513 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc18a3a-201
(1)
|
Ensembl | 2,406 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232K3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153442 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192476 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077550 (1) | 2423 nt | ||
| Genomic | GenBank:BX855592 (1) | 159646 nt | ||
| Polypeptide | UniProtKB:B2GS60 (1) | 513 aa |
- Howard, A.G., Baker, P.A., Ibarra-García-Padilla, R., Moore, J.A., Rivas, L.J., Tallman, J.J., Singleton, E.W., Westheimer, J.L., Corteguera, J.A., Uribe, R.A. (2021) An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. eLIFE. 10:
- Zhang, H., Wang Haifang, H., Shen, X., Jia, X., Yu, S., Qiu, X., Wang, Y., Du, J., Yan, J., He, J. (2021) The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain. eLIFE. 10:
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Liu, S., Yu, M., Xie, X., Ru, Y., Ru, S. (2020) Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. 253:126635
- Rima, M., Lattouf, Y, Abi Younes, M., Bullier, E., Legendre, P., Mangin, J.M., Hong, E. (2020) Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific Reports. 10(1):15338
- Henriques, P.M., Rahman, N., Jackson, S.E., Bianco, I.H. (2019) Nucleus Isthmi Is Required to Sustain Target Pursuit during Visually Guided Prey-Catching. Current biology : CB. 29(11):1771-1786.e5
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lovett-Barron, M., Andalman, A.S., Allen, W.E., Vesuna, S., Kauvar, I., Burns, V.M., Deisseroth, K. (2017) Ancestral Circuits for the Coordinated Modulation of Brain State. Cell. 171(6):1411-1423.e17
- Taniguchi, A., Kimura, Y., Mori, I., Nonaka, S., Higashijima, S.I. (2017) Axially-confined in vivo single-cell labeling by primed conversion using blue and red lasers with conventional confocal microscopes. Development, growth & differentiation. 59(9):741-748
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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