tyw1

ID

ZDB-GENE-060929-688

Name

tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

Symbol

tyw1 Nomenclature History

Previous Names

im:6898509
wu:fb74d01
zgc:153368

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; FMN binding activity; and tRNA-4-demethylwyosine synthase activity. Predicted to be involved in wybutosine biosynthetic process. Predicted to act upstream of or within tRNA processing. Predicted to be located in membrane. Orthologous to human TYW1 (tRNA-yW synthesizing protein 1 homolog) and TYW1B (tRNA-yW synthesizing protein 1 homolog B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6898509 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tyw1 Human Ortholog

No data available

Associated With tyw1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001094	Flavodoxin-like
Domain	IPR007197	Radical SAM
Domain	IPR008254	Flavodoxin/nitric oxide synthase
Domain	IPR013917	tRNA wybutosine-synthesis
Family	IPR034556	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR029039	Flavoprotein-like superfamily