Gene
smyd4
- ID
- ZDB-GENE-060929-248
- Name
- SET and MYND domain containing 4
- Symbol
- smyd4 Nomenclature History
- Previous Names
-
- smynd4
- zgc:153385 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable histone deacetylase binding activity. Acts upstream of or within heart looping and negative regulation of histone deacetylase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in blood vessel; cardiac ventricle; heart; heart tube; and polster. Used to study congenital heart disease. Orthologous to human SMYD4 (SET and MYND domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Xiao et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Xiao et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | smyd4zf3020/zf3020; zf2036Tg | standard conditions | Xiao et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001214 | SET domain |
| Domain | IPR002893 | Zinc finger, MYND-type |
| Domain | IPR044421 | SMYD4, SET domain |
| Family | IPR052097 | SET and MYND domain-containing protein |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | SET and MYND domain-containing protein | SET domain | SET domain superfamily | SMYD4, SET domain | Tetratricopeptide-like helical domain superfamily | Zinc finger, MYND-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PTN1
|
727 | ||||||
|
UniProtKB:Q08C84
|
753 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available