afg2b

ID

ZDB-GENE-060929-204

Name

AAA ATPase AFG2B

Symbol

afg2b Nomenclature History

Previous Names

spata5l1
wu:fi26h05
wu:fi39b02
zgc:153294 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ATP hydrolysis activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in autophagosome maturation; mitotic spindle disassembly; and proteasomal protein catabolic process. Predicted to be located in spindle. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human AFG2B (AAA ATPase AFG2B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With afg2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Deafness, autosomal recessive 119	619615
		Neurodevelopmental disorder with hearing loss and spasticity	619616

Associated With afg2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR050168	AAA ATPase domain-containing protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase