Gene
runx1t1
- ID
- ZDB-GENE-060929-164
- Name
- RUNX1 partner transcriptional co-repressor 1
- Symbol
- runx1t1 Nomenclature History
- Previous Names
-
- wu:fi14b07
- zgc:154044
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within DNA-templated transcription. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa29233 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CBFA2T family | NHR2-like | Protein CBFA2T1 | TAFH/NHR1 | TAFH/NHR1 domain superfamily | Zinc finger, MYND-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1L8K2 | InterPro | 588 | ||||||
| UniProtKB:A0A0R4IXV4 | InterPro | 591 | ||||||
| UniProtKB:A0A8M6YUK0 | InterPro | 590 | ||||||
| UniProtKB:E9QDS4 | InterPro | 585 | ||||||
| UniProtKB:A0AB32T784 | InterPro | 635 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
runx1t1-205
(1)
|
Ensembl | 745 nt | ||
| mRNA |
runx1t1-201
(1)
|
Ensembl | 1,758 nt | ||
| mRNA |
runx1t1-202
(1)
|
Ensembl | 1,305 nt | ||
| mRNA |
runx1t1-203
(1)
|
Ensembl | 5,244 nt | ||
| mRNA |
runx1t1-204
(1)
|
Ensembl | 632 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232J17 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-79C4 | ZFIN Curated Data | |
| Encodes | EST | fi14b07 | ||
| Encodes | EST | fj53h11 | ||
| Encodes | cDNA | MGC:154044 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001076776 (1) | 2159 nt | ||
| Genomic | GenBank:CR759910 (2) | 217814 nt | ||
| Polypeptide | UniProtKB:A0AB32T784 (1) | 635 aa |
- Falisse, E., Ducos, B., Stockwell, P.A., Morison, I.M., Chatterjee, A., Silvestre, F. (2018) DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Environmental pollution (Barking, Essex : 1987). 243:1867-1877
- Liu, J., Xiang, C., Huang, W., Mei, J., Sun, L., Ling, Y., Wang, C., Wang, X., Dahlgren, R.A., Wang, H. (2018) Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 206:176-185
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Demir, K., Kirsch, N., Beretta, C.A., Erdmann, G., Ingelfinger, D., Moro, E., Argenton, F., Carl, M., Niehrs, C., and Boutros, M. (2013) RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Reports. 4(6):1224-1234
- Yang, H., Zhou, Y., Gu, J., Xie, S., Xu, Y., Zhu, G., Wang, L., Huang, J., Ma, H., and Yao, J. (2013) Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One. 8(5):e64058
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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