Gene
prkag2a
- ID
- ZDB-GENE-060929-160
- Name
- protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
- Symbol
- prkag2a Nomenclature History
- Previous Names
-
- zgc:153329
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to act upstream of or within fatty acid biosynthetic process and phosphorylation. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yang et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37913 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypertrophic cardiomyopathy 6 | Alliance | Cardiomyopathy, hypertrophic 6 | 600858 |
| lethal congenital glycogen storage disease of heart | Alliance | Glycogen storage disease of heart, lethal congenital | 261740 |
| Wolff-Parkinson-White syndrome | Alliance | Wolff-Parkinson-White syndrome | 194200 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AMP-activated protein kinase gamma/SDS23 families | CBS domain | CBS domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1QJ49 | InterPro | 436 | |||
| UniProtKB:A0A8M3APB3 | InterPro | 543 | |||
| UniProtKB:A0A8M9PG44 | InterPro | 547 | |||
| UniProtKB:A0A8M9PLX0 | InterPro | 528 | |||
| UniProtKB:A0A8M9PXM0 | InterPro | 440 | |||
| UniProtKB:F8W5P9 | InterPro | 330 | |||
| UniProtKB:A0AB32TCT6 | InterPro | 442 | |||
| UniProtKB:A0AB32TGW3 | InterPro | 530 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkag2a-201
(1)
|
Ensembl | 2,977 nt | ||
| mRNA |
prkag2a-202
(1)
|
Ensembl | 1,024 nt | ||
| mRNA |
prkag2a-204
(1)
|
Ensembl | 2,577 nt | ||
| mRNA |
prkag2a-205
(1)
|
Ensembl | 900 nt | ||
| mRNA |
prkag2a-206
(1)
|
Ensembl | 772 nt | ||
| ncRNA |
prkag2a-005
(1)
|
Ensembl | 897 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-295J8 | ZFIN Curated Data | |
| Contained in | BAC | CH73-367C9 | ZFIN Curated Data | |
| Contained in | BAC | CH73-390I7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153329 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328430 (1) | 2977 nt | ||
| Genomic | GenBank:CU694811 (2) | 90738 nt | ||
| Polypeptide | UniProtKB:A0A8M9PG44 (1) | 547 aa |
- Yang, B.Y., Zhai, G., Gong, Y.L., Su, J.Z., Peng, X.Y., Shang, G.H., Han, D., Jin, J.Y., Liu, H.K., Du, Z.Y., Yin, Z., Xie, S.Q. (2017) Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American journal of physiology. Endocrinology and metabolism. 315(1):E38-E51
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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