Gene

prkag2a

ID

ZDB-GENE-060929-160

Name

protein kinase, AMP-activated, gamma 2 non-catalytic subunit a

Symbol

prkag2a Nomenclature History

Previous Names

zgc:153329

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have adenyl ribonucleotide binding activity. Predicted to be involved in regulation of protein serine/threonine kinase activity. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Yang et al., 2017

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkag2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypertrophic cardiomyopathy 6	Alliance	Cardiomyopathy, hypertrophic 6	600858
lethal congenital glycogen storage disease of heart	Alliance	Glycogen storage disease of heart, lethal congenital	261740
Wolff-Parkinson-White syndrome	Alliance	Wolff-Parkinson-White syndrome	194200

Associated With prkag2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000644	CBS domain
Homologous_superfamily	IPR046342	CBS domain superfamily

Domain Details Per Protein

Protein	Length	CBS domain	CBS domain superfamily
UniProtKB:F1QJ49 InterPro	436
UniProtKB:A0A8M3APB3 InterPro	543
UniProtKB:A0A8M9PG44 InterPro	547
UniProtKB:A0A8M9PLX0 InterPro	528
UniProtKB:A0A8M9PXM0 InterPro	440
UniProtKB:F8W5P9 InterPro	330

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prkag2a-202 (1) Ensembl	Havana	1024 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prkag2a-204 (1) Ensembl	Havana	2577 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prkag2a-205 (1) Ensembl	Havana	900 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prkag2a-206 (1) Ensembl	Havana	772 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	prkag2a-005 (1) Ensembl	Havana	897 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations