Gene

mtfmt

ID

ZDB-GENE-060929-120

Name

mitochondrial methionyl-tRNA formyltransferase

Symbol

mtfmt Nomenclature History

Previous Names

zgc:152651

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and mitochondrial complex I deficiency. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mtfmt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 15	Alliance	Combined oxidative phosphorylation deficiency 15	614947
nuclear type mitochondrial complex I deficiency 27	Alliance	Mitochondrial complex I deficiency, nuclear type 27	618248

Associated With mtfmt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002376	Formyl transferase, N-terminal
Domain	IPR005793	Formyl transferase, C-terminal
Domain	IPR041711	Methionyl-tRNA formyltransferase, N-terminal domain
Family	IPR005794	Methionyl-tRNA formyltransferase
Homologous_superfamily	IPR036477	Formyl transferase, N-terminal domain superfamily