ZFIN is now using GRCz12tu for Genomic Data

Gene

rnf220a

ID

ZDB-GENE-060929-1006

Name

ring finger protein 220a

Symbol

rnf220a Nomenclature History

Previous Names

zgc:153254

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ubiquitin protein ligase activity. Involved in spinal cord patterning. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ma et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnf220a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypomyelinating leukodystrophy 23	Alliance	Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy	619688

Associated With rnf220a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR031824	E3 ubiquitin-protein ligase RNF220, middle domain
Domain	IPR040178	E3 ubiquitin-protein ligase RNF220, RING finger
Family	IPR052443	E3 ubiquitin-protein ligase RNF220-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9QNG6	InterPro	669
UniProtKB:A0A8M9PY31	InterPro	333
UniProtKB:A0A8M9Q9U5	InterPro	634
UniProtKB:A0A8M9PY03	InterPro	638
UniProtKB:A0A8M9QJR7	InterPro	660
UniProtKB:A0A8M9QJS5	InterPro	399
UniProtKB:A0A8M9QFI1	InterPro	577
UniProtKB:A0A8M9QFJ4	InterPro	307
UniProtKB:A0A8M9Q9V4	InterPro	364
UniProtKB:Q08CD0	InterPro	307
UniProtKB:A0A8M9PXZ7	InterPro	695
UniProtKB:A0A8M9QFH8	InterPro	615
UniProtKB:A0A8M9PY10	InterPro	603
UniProtKB:A0A8M9Q9V8	InterPro	338
UniProtKB:A0AC58GY98	InterPro	695
UniProtKB:A0AC58GYA0	InterPro	695
UniProtKB:A0AC58GYB0	InterPro	695
UniProtKB:A0AC58GYD5	InterPro	638
UniProtKB:A0AC58GYF0	InterPro	638
UniProtKB:A0AC58GYF4	InterPro	638
UniProtKB:A0AC58GYF5	InterPro	638
UniProtKB:A0AC58GYH2	InterPro	638
UniProtKB:A0AC58GYI3	InterPro	612
UniProtKB:A0AC58GYI5	InterPro	612
UniProtKB:A0AC58GYJ2	InterPro	612
UniProtKB:A0AC58GYK3	InterPro	612
UniProtKB:A0AC58GYL2	InterPro	612
UniProtKB:A0AC58GYM2	InterPro	603
UniProtKB:A0AC58GYM8	InterPro	603
UniProtKB:A0AC58GYN7	InterPro	603
UniProtKB:A0AC58GYP5	InterPro	603
UniProtKB:A0AC58GYQ0	InterPro	603
UniProtKB:A0AC58GYR4	InterPro	603
UniProtKB:A0AC58GYS6	InterPro	603
UniProtKB:A0AC58GYT3	InterPro	589
UniProtKB:A0AC58GYU1	InterPro	580
UniProtKB:A0AC58GYV0	InterPro	558
UniProtKB:A0AC58GYV4	InterPro	577
UniProtKB:A0AC58GYV6	InterPro	577
UniProtKB:A0AC58GYV7	InterPro	577
UniProtKB:A0AC58GYV9	InterPro	577
UniProtKB:A0AC58GYW4	InterPro	373
UniProtKB:A0AC58GYW8	InterPro	554
UniProtKB:A0AC58GYW9	InterPro	497
UniProtKB:A0AC58GYX3	InterPro	399
UniProtKB:A0AC58GYX6	InterPro	523
UniProtKB:A0AC58GYY0	InterPro	342
UniProtKB:A0AC58GYY1	InterPro	338
UniProtKB:A0AC58GYY2	InterPro	333
UniProtKB:A0AC58GYZ0	InterPro	364
UniProtKB:A0AC58GZ01	InterPro	333
UniProtKB:A0AC58GZ04	InterPro	316
UniProtKB:A0AC58GZ10	InterPro	307
UniProtKB:A0AC58GZ20	InterPro	293
UniProtKB:A0AC58GZ21	InterPro	307

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	rnf220a-205 (1) Ensembl	Ensembl	855 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-201 (1) Ensembl	Ensembl	1,614 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-202 (1) Ensembl	Ensembl	1,734 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-203 (1) Ensembl	Ensembl	762 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-204 (1) Ensembl	Ensembl	694 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-206 (1) Ensembl	Ensembl	604 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-207 (1) Ensembl	Ensembl	1,339 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-208 (1) Ensembl	Ensembl	2,707 nt	Select Tool ZFIN BLAST
mRNA	rnf220a-209 (1) Ensembl	Ensembl	5,466 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations