ZFIN is now using GRCz12tu for Genomic Data
Gene

pcsk9

ID
ZDB-GENE-060927-1
Name
proprotein convertase subtilisin/kexin type 9
Symbol
pcsk9 Nomenclature History
Previous Names
  • NARC-1 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within central nervous system development and neurogenesis. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and lysosome. Predicted to be active in extracellular space. Is expressed in several structures, including eye; integument; liver; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcsk9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hypercholesterolemia, familial, 3 603776
{Low density lipoprotein cholesterol level QTL 1} 603776
Associated With pcsk9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9
Domain IPR034193 Proteinase K-like catalytic domain
Domain IPR041051 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3
Domain IPR041254 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1
Family IPR015500 Peptidase S8, subtilisin-related
Family IPR050131 Subtilisin-like serine protease
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Homologous_superfamily IPR037045 Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Domain Details Per Protein
Protein Additional Resources Length Peptidase S8 propeptide/proteinase inhibitor I9 Peptidase S8 propeptide/proteinase inhibitor I9 superfamily Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3 Proteinase K-like catalytic domain Subtilisin-like serine protease
UniProtKB:E7F2J6 InterPro 667
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pcsk9-201 (1)
Ensembl
Ensembl 2,004 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pcsk9 polyclonal Rabbit
  • WB
 1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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