Gene
llgl1
- ID
- ZDB-GENE-060825-69
- Name
- LLGL scribble cell polarity complex component 1
- Symbol
- llgl1 Nomenclature History
- Previous Names
-
- zgc:153337
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and myosin II binding activity. Acts upstream of with a positive effect on cell projection assembly. Acts upstream of or within several processes, including heart development; limb epidermis development; and sensory system development. Located in basolateral plasma membrane. Is expressed in central nervous system; eye; head; and retina. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-llgl1 | Pollitt et al., 2024 | |
| MO1-llgl1 | N/A | (5) |
| MO2-llgl1 | N/A | (3) |
| TALEN1-llgl1 | Flinn et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013577 | Lethal giant larvae homologue 2 |
| Domain | IPR013905 | Lethal giant larvae (Lgl)-like, C-terminal domain |
| Family | IPR000664 | Lethal(2) giant larvae protein |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Lethal(2) giant larvae protein | Lethal giant larvae homologue 2 | Lethal giant larvae (Lgl)-like, C-terminal domain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:I0BWE2 | InterPro | 1040 | ||||||
| UniProtKB:A0A8M9PXW4 | InterPro | 1040 | ||||||
| UniProtKB:A0A8M2BBF6 | InterPro | 1041 | ||||||
| UniProtKB:E7FD67 | InterPro | 1040 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myl7:llgl1-mCherry) |
|
| 1 | Pollitt et al., 2024 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-209H5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-19E10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153337 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045469 (1) | 3123 nt | ||
| Genomic | GenBank:BX649547 (1) | 237569 nt | ||
| Polypeptide | UniProtKB:A0A8M2BBF6 (1) | 1041 aa |
- Pollitt, E.J.G., Sánchez-Posada, J., Snashall, C.M., Derrick, C.J., Noël, E.S. (2024) Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development (Cambridge, England). 151(13):
- Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103
- Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
- Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
- Magre, I., Fandade, V., Damle, I., Banerjee, P., Yadav, S.K., Sonawane, M., Joseph, J. (2019) Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis. Journal of Cell Science. 132(12):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Raman, R., Damle, I., Rote, R., Banerjee, S., Dingare, C., Sonawane, M. (2016) aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis. Nature communications. 7:11643
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Clark, B.S., Cui, S., Miesfeld, J.B., Klezovitch, O., Vasioukhin, V., and Link, B.A. (2012) Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. Development (Cambridge, England). 139(9):1599-1610
- Johnson, J.L., Hall, T.E., Dyson, J.M., Sonntag, C., Ayers, K., Berger, S., Gautier, P., Mitchell, C., Hollway, G.E., and Currie, P.D. (2012) Scube activity is necessary for Hedgehog signal transduction in vivo. Developmental Biology. 368(2):193-202
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