Gene

llgl1

ID

ZDB-GENE-060825-69

Name

LLGL scribble cell polarity complex component 1

Symbol

llgl1 Nomenclature History

Previous Names

zgc:153337

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity and myosin II binding activity. Acts upstream of with a positive effect on cell projection assembly. Acts upstream of or within several processes, including heart development; limb epidermis development; and sensory system development. Located in basolateral plasma membrane. Is expressed in central nervous system; eye; head; and retina. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 25 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With llgl1 Human Ortholog

No data available

Associated With llgl1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013577	Lethal giant larvae homologue 2
Domain	IPR013905	Lethal giant larvae (Lgl)-like, C-terminal domain
Family	IPR000664	Lethal(2) giant larvae protein
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Lethal(2) giant larvae protein	Lethal giant larvae homologue 2	Lethal giant larvae (Lgl)-like, C-terminal domain	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:I0BWE2 InterPro	1040
UniProtKB:A0A8M9PXW4 InterPro	1040
UniProtKB:A0A8M2BBF6 InterPro	1041
UniProtKB:E7FD67 InterPro	1040

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	llgl1-201 (1) Ensembl	Ensembl	3,123 nt	Select Tool ZFIN BLAST
mRNA	llgl1-202 (1) Ensembl	Ensembl	1,059 nt	Select Tool ZFIN BLAST
mRNA	llgl1-203 (1) Ensembl	Ensembl	1,372 nt	Select Tool ZFIN BLAST
mRNA	llgl1-204 (1) Ensembl	Ensembl	5,400 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-llgl1	polyclonal	llgl1		Rabbit	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations