Gene
frmd7
- ID
- ZDB-GENE-060825-67
- Name
- FERM domain containing 7
- Symbol
- frmd7 Nomenclature History
- Previous Names
-
- zgc:153674
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton and membrane. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to human FRMD7 (FERM domain containing 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nystagmus 1 | Alliance | Nystagmus 1, congenital, X-linked | 310700 |
| congenital nystagmus 1 | Alliance | Nystagmus, infantile periodic alternating, X-linked | 310700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019747 | FERM conserved site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR014847 | FERM adjacent |
| Domain | IPR018979 | FERM, N-terminal |
| Domain | IPR018980 | FERM, C-terminal PH-like domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR041788 | FARP1/FARP2/FRMD7, FERM domain C-lobe |
| Family | IPR000798 | Ezrin/radixin/moesin-like |
| Family | IPR051835 | RAC1-specific guanine nucleotide exchange factor |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | Ezrin/radixin/moesin-like | FARP1/FARP2/FRMD7, FERM domain C-lobe | FERM/acyl-CoA-binding protein superfamily | FERM adjacent | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | PH-like domain superfamily | RAC1-specific guanine nucleotide exchange factor | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PCT6 | InterPro | 300 | ||||||||||||||
| UniProtKB:A0A8M2BL62 | InterPro | 722 | ||||||||||||||
| UniProtKB:F1R8Z1 | InterPro | 253 | ||||||||||||||
| UniProtKB:A0A8M9PQL4 | InterPro | 497 |
Interactions and Pathways
No data available
Plasmids
No data available