Gene

gck

ID
ZDB-GENE-060825-204
Name
glucokinase (hexokinase 4)
Symbol
gck Nomenclature History
Previous Names
  • DrGLK (1)
  • fb57f10
  • hex4 (1)
  • wu:fb57f10 (1)
  • zgc:153643
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have fructokinase activity; glucokinase activity; and mannokinase activity. Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to cytosol and mitochondrion. Is expressed in brain; digestive system; female organism; heart; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gck Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hyperinsulinemic hypoglycemia 3 Alliance Hyperinsulinemic hypoglycemia, familial, 3 602485
maturity-onset diabetes of the young type 2 Alliance MODY, type II 125851
permanent neonatal diabetes mellitus Alliance Diabetes mellitus, permanent neonatal 1 606176
type 2 diabetes mellitus Alliance Diabetes mellitus, noninsulin-dependent, late onset 125853
Associated With gck Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR019807 Hexokinase, binding site
Domain IPR022672 Hexokinase, N-terminal
Domain IPR022673 Hexokinase, C-terminal
Family IPR001312 Hexokinase
Family IPR039073 Hexokinase-4, chordate
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length ATPase, nucleotide binding domain Hexokinase Hexokinase-4, chordate Hexokinase, binding site Hexokinase, C-terminal Hexokinase, N-terminal
UniProtKB:F1RC38 476
UniProtKB:B8A4K2 298
UniProtKB:Q0P400 274
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations