Gene

pde5ab

ID

ZDB-GENE-060824-4

Name

phosphodiesterase 5A, cGMP-specific, b

Symbol

pde5ab Nomenclature History

Previous Names

pde5a

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Li et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde5ab Human Ortholog

No data available

Associated With pde5ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003018	GAF domain
Domain	IPR003607	HD/PDEase domain
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR029016	GAF-like domain superfamily
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	3'5'-cyclic nucleotide phosphodiesterase	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	3'5'-cyclic nucleotide phosphodiesterase, conserved site	GAF domain	GAF-like domain superfamily	HD/PDEase domain
UniProtKB:A0A8M2BE10 InterPro	868
UniProtKB:B0S7D6 InterPro	867
UniProtKB:A0A8M3BBB2 InterPro	865

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pde5ab-201 (1) Ensembl	Ensembl	2,613 nt	Select Tool ZFIN BLAST
mRNA	pde5ab-203 (1) Ensembl	Ensembl	2,742 nt	Select Tool ZFIN BLAST
ncRNA	pde5ab-003 (1) Ensembl	Ensembl	1,665 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-pde5a	polyclonal	pde5ab	IgG	Rabbit	IHC WB	GeneTex	2
Ab1-pde5a	polyclonal	pde5ab		Rabbit	IHC WB	Aviva Systems Biology	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations