Gene
zp2l1
- ID
- ZDB-GENE-060818-3
- Name
- zona pellucida glycoprotein 2, like 1
- Symbol
- zp2l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to several human genes including ZP4 (zona pellucida glycoprotein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Miao et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa34695 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-type trefoil domain | P-type trefoil domain superfamily | Zona pellucida domain | Zona Pellucida Domain Glycoprotein | Zona pellucida, ZP-C domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A7MBW8 | InterPro | 404 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-202N12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171732 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105104 (1) | 1290 nt | ||
| Genomic | GenBank:CT030134 (1) | 146368 nt | ||
| Polypeptide | UniProtKB:A7MBW8 (1) | 404 aa |
No data available
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Wu, T., Cheng, Y., Liu, Z., Tao, W., Zheng, S., Wang, D. (2018) Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Fish physiology and biochemistry. 44(2):435-449
- Miao, L., Yuan, Y., Cheng, F., Fang, J., Zhou, F., Ma, W., Jiang, Y., Huang, X., Wang, Y., Shan, L., Chen, D., Zhang, J. (2017) Translation repression by maternal RNA binding protein zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). 144(1):128-138
- Liu, X., Wang, H., and Gong, Z. (2006) Tandem-Repeated Zebrafish zp3 Genes Possess Oocyte-Specific Promoters and Are Insensitive to Estrogen Induction. Biology of reproduction. 74(6):1016-1025
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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