Gene
kdm5c
- ID
- ZDB-GENE-060810-94
- Name
- lysine demethylase 5C
- Symbol
- kdm5c Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have histone demethylase activity (H3-trimethyl-K4 specific). Involved in negative regulation of neuron apoptotic process. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Claes-Jensen type. Is expressed in brain; head; muscle; and spinal cord. Orthologous to several human genes including KDM5C (lysine demethylase 5C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158173 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked intellectual disability Claes-Jensen type | Alliance | Intellectual developmental disorder, X-linked syndromic, Claes-Jensen type | 300534 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001606 | ARID DNA-binding domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003347 | JmjC domain |
| Domain | IPR003349 | JmjN domain |
| Domain | IPR004198 | Zinc finger, C5HC2-type |
| Domain | IPR013637 | Lysine-specific demethylase-like domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR048615 | Lysine-specific demethylase 5, C-terminal helical domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036431 | ARID DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ARID DNA-binding domain | ARID DNA-binding domain superfamily | JmjC domain | JmjN domain | Lysine-specific demethylase 5, C-terminal helical domain | Lysine-specific demethylase-like domain | Zinc finger, C5HC2-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z830
|
1559 | ||||||||||||
|
UniProtKB:B0S6L0
|
1578 |
Interactions and Pathways
No data available
Plasmids
No data available