ZFIN ID: ZDB-GENE-060810-93
Gene Name: T-box brain transcription factor 1a
Gene Symbol: tbr1a    Nomenclature History

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Previous Name: im:7158160

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including generation of neurons; heart looping; and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in olfactory placode and peripheral olfactory organ. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1).
Genome Resources: Alliance (1),  Gene:564699 (1),  Ensembl(GRCz11):ENSDARG00000076259 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [IMAGE:7158160]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21854 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tbr1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder with autism and speech delay 606053
    DISEASE ASSOCIATED WITH tbr1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbr1a-201 (1)    Ensembl 1805
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbr1a No data available
    MARKER RELATIONSHIPS
    tbr1a Contained in: [BAC] DKEY-16N9 (order this)
    tbr1a Encodes: [EST] IMAGE:7158160 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_688029 (1) 1984 nt
    Genomic GenBank:CR450841 (1) 263287 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7FCP0 (1) 585 aa
    Sequence Information (all 6)
    ORTHOLOGY for tbr1a ( Chr: 11 )
    CITATIONS (20)