Gene
rad54b
- ID
- ZDB-GENE-060810-50
- Name
- RAD54 homolog B
- Symbol
- rad54b Nomenclature History
- Previous Names
-
- im:7137737
- im:7153525
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA translocase activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, somatic | 114500 |
| non-Hodgkin lymphoma | Alliance | Lymphoma, non-Hodgkin, somatic | 605027 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD54 Helicase and DNA Repair | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QHY4 | InterPro | 917 | |||||||
| UniProtKB:A0AB32T594 | InterPro | 757 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rad54b-201
(1)
|
Ensembl | 3,229 nt | ||
| mRNA |
rad54b-202
(1)
|
Ensembl | 1,926 nt | ||
| mRNA |
rad54b-203
(1)
|
Ensembl | 2,532 nt | ||
| mRNA |
rad54b-204
(1)
|
Ensembl | 2,571 nt | ||
| mRNA |
rad54b-205
(1)
|
Ensembl | 2,535 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-79L20 | ||
| Encodes | EST | IMAGE:7137737 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7153525 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_683887 (1) | 3262 nt | ||
| Genomic | GenBank:BX511010 (1) | 156317 nt | ||
| Polypeptide | UniProtKB:E9QHY4 (1) | 917 aa |
- Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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