Gene
ptbp2b
- ID
- ZDB-GENE-060810-49
- Name
- polypyrimidine tract binding protein 2b
- Symbol
- ptbp2b Nomenclature History
- Previous Names
-
- ptbp2
- im:7153495
- si:ch211-160l17.2
- wu:fa08f05
- wu:fc05d10
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Is expressed in central nervous system; cranial ganglion; retinal ganglion cell layer; and retinal inner nuclear layer. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153495 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR021790 | PTBP1-like, RNA recognition motif 2 |
| Domain | IPR035002 | PTBP2, RNA recognition motif 1 |
| Family | IPR006536 | HnRNP-L/PTB |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | HnRNP-L/PTB | Nucleotide-binding alpha-beta plait domain superfamily | PTBP1-like, RNA recognition motif 2 | PTBP2, RNA recognition motif 1 | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAH6 | InterPro | 518 | ||||||
| UniProtKB:A5PM68 | InterPro | 538 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
ptbp2b-203
(1)
|
Ensembl | 759 nt | ||
| mRNA |
ptbp2b-201
(1)
|
Ensembl | 2,900 nt | ||
| mRNA |
ptbp2b-204
(1)
|
Ensembl | 281 nt | ||
| ncRNA |
ptbp2b-003
(1)
|
Ensembl | 518 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160L17 | ZFIN Curated Data | |
| Encodes | EST | fa08f05 | ||
| Encodes | EST | fc05d10 | ||
| Encodes | EST | IMAGE:7153495 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100007 (1) | 2826 nt | ||
| Genomic | GenBank:BX005269 (1) | 185170 nt | ||
| Polypeptide | UniProtKB:A5PM68 (1) | 538 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
- Hultqvist, G., Daza, D.O., Larhammar, D., and Kilimann, M.W. (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One. 7(7):e41850
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