ZFIN is now using GRCz12tu for Genomic Data
Gene
topbp1
- ID
- ZDB-GENE-060626-1
- Name
- DNA topoisomerase II binding protein 1
- Symbol
- topbp1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within DNA damage response; definitive hemopoiesis; and regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in nucleus. Is expressed in caudal fin and head. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gao et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gao et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | DNA topoisomerase 2-binding protein 1, eighth BRCT domain | DNA topoisomerase 2-binding protein 1-like, BRCT0 domain | TopBP1, first BRCT domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1R135 | InterPro | 1520 | |||||
| UniProtKB:A0A2R8RVN3 | InterPro | 1526 | |||||
| UniProtKB:A0A8M6YVL2 | InterPro | 1519 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
topbp1-201
(1)
|
Ensembl | 7,055 nt | ||
| mRNA |
topbp1-202
(1)
|
Ensembl | 4,697 nt | ||
| mRNA |
topbp1-203
(1)
|
Ensembl | 4,691 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers