Gene
tlk2
- ID
- ZDB-GENE-060623-36
- Name
- tousled-like kinase 2
- Symbol
- tlk2 Nomenclature History
- Previous Names
-
- wu:fi16h09
- wu:fi30g12
- zgc:136697
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm; cytoskeleton; and nucleoplasm. Predicted to be active in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TLK2 (tousled like kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015102Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10364 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14440 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18506 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26040 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45138 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab325 | Allele with one deletion | Unknown | Unknown | CRISPR |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 57 | Alliance | Intellectual developmental disorder, autosomal dominant 57 | 618050 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QUZ6 | InterPro | 697 | ||||
| UniProtKB:A0A8M9PXE3 | InterPro | 696 | ||||
| UniProtKB:Q1ECX4 | InterPro | 697 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202G13 | ZFIN Curated Data | |
| Encodes | EST | fi16h09 | ||
| Encodes | EST | fi30g12 | ||
| Encodes | cDNA | MGC:136697 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173515 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198229 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110417 (1) | 3949 nt | ||
| Genomic | GenBank:BX572620 (1) | 199512 nt | ||
| Polypeptide | UniProtKB:A0A2R8QUZ6 (1) | 697 aa |
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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