Gene

alox5b.2

ID

ZDB-GENE-060623-19

Name

arachidonate 5-lipoxygenase b, tandem duplicate 2

Symbol

alox5b.2 Nomenclature History

Previous Names

ALOX3b (1)
zgc:136911

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have iron ion binding activity and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox5b.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma	Alliance	{Asthma, diminished response to antileukotriene treatment in}	600807
		{Atherosclerosis, susceptibility to}

Associated With alox5b.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020833	Lipoxygenase, iron binding site
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Domain	IPR042062	Lipoxygenase, vertebrates, PLAT domain
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily