Gene
ank3a
- ID
- ZDB-GENE-060621-1
- Name
- ankyrin 3a
- Symbol
- ank3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Is expressed in heart; lens; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in alcohol-related birth defects; autosomal recessive intellectual developmental disorder 37; bipolar disorder; post-traumatic stress disorder; and schizophrenia. Orthologous to human ANK3 (ankyrin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Owen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013059Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019978Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019979Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019980Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019981Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027822Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9548 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13397 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15975 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17048 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ank3a | N/A | Voas et al., 2009 |
| MO2-ank3a | N/A | Owen et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 37 | Alliance | Intellectual developmental disorder, autosomal recessive 37 | 615493 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin-3, death domain | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ankyrin, UPA domain | Death domain | Death-like domain superfamily | Multifunctional Ankyrin Repeat Domain-Containing Protein | ZU5 domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q287 | InterPro | 4486 | ||||||||
| UniProtKB:A0A8M3AJS7 | InterPro | 3692 | ||||||||
| UniProtKB:A0A8M9PVB2 | InterPro | 4463 | ||||||||
| UniProtKB:A0A8M3AR97 | InterPro | 4499 | ||||||||
| UniProtKB:A0A8M3ARB3 | InterPro | 4180 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-239N21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-29H4 | ZFIN Curated Data |
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