ZFIN is now using GRCz12tu for Genomic Data
Gene
ank3a
- ID
- ZDB-GENE-060621-1
- Name
- ankyrin 3a
- Symbol
- ank3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in protein localization to plasma membrane. Predicted to be located in several cellular components, including T-tubule; lysosome; and postsynaptic membrane. Is expressed in heart; lens; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in alcohol-related birth defects; autosomal recessive intellectual developmental disorder 37; bipolar disorder; post-traumatic stress disorder; and schizophrenia. Orthologous to human ANK3 (ankyrin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Owen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 37 | Alliance | Intellectual developmental disorder, autosomal recessive 37 | 615493 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000488 | Death domain |
| Domain | IPR000906 | ZU5 domain |
| Domain | IPR037971 | Ankyrin-3, death domain |
| Domain | IPR040745 | Ankyrin, UPA domain |
| Family | IPR051165 | Multifunctional Ankyrin Repeat Domain-Containing Protein |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ank3a-201
(1)
|
Ensembl | 5,313 nt | ||
| mRNA |
ank3a-202
(1)
|
Ensembl | 12,453 nt | ||
| mRNA |
ank3a-204
(1)
|
Ensembl | 523 nt | ||
| mRNA |
ank3a-205
(1)
|
Ensembl | 5,850 nt | ||
| mRNA |
ank3a-206
(1)
|
Ensembl | 540 nt | ||
| mRNA |
ank3a-207
(1)
|
Ensembl | 795 nt | ||
| ncRNA |
ank3a-004
(1)
|
Ensembl | 740 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers