Gene
thrab
- ID
- ZDB-GENE-060613-1
- Name
- thyroid hormone receptor alpha b
- Symbol
- thrab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Acts upstream of or within heart development and positive regulation of sarcomere organization. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including blastodisc; cardiovascular system; mandibular arch skeleton; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017632 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nci103 | Allele with one delins | Unknown | Unknown | CRISPR | |
| nci104 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa35284 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42020 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42021 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| vp31rc1 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-thrab | Lazcano et al., 2019 | |
| CRISPR2-thrab | (4) | |
| CRISPR3-thrab | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 6 | Alliance | Hypothyroidism, congenital, nongoitrous, 6 | 614450 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
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Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:U3JAT9
|
409 | |||||||
|
UniProtKB:A0A8M3B4P5
|
419 | |||||||
|
UniProtKB:A0A8M3AYH1
|
411 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-176J23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-194J3 | ||
| Contained in | BAC | DKEY-48K21 | ZFIN Curated Data | |
| Encodes | EST | dq017632 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306720 (1) | 8370 nt | ||
| Genomic | GenBank:BX510316 (1) | 189720 nt | ||
| Polypeptide | UniProtKB:A0A8M3B4P5 (1) | 419 aa |
- Ai, N., Han, C.R., Zhao, H., Cheng, S.Y., Ge, W. (2024) Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish. Endocrinology. 165(5):
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Harper, M., Hu, Y., Donahue, J., Acosta, B., Dievenich Braes, F., Nguyen, S., Zeng, J., Barbaro, J., Lee, H., Bui, H., McMenamin, S.K. (2023) Thyroid hormone regulates proximodistal patterning in fin rays. Proceedings of the National Academy of Sciences of the United States of America. 120:e2219770120e2219770120
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M. (2021) Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development. Developmental Biology. 477:205-218
- Guzzolino, E., Milella, M.S., Forini, F., Borsò, M., Rutigliano, G., Gorini, F., Zucchi, R., Saba, A., Bianchi, F., Iervasi, G., Pitto, L. (2021) Thyroid disrupting effects of low-dose dibenzothiophene and cadmium in single or concurrent exposure: New evidence from a translational zebrafish model. The Science of the total environment. 769:144703
- Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104
- Han, C.R., Holmsen, E., Carrington, B., Bishop, K., Zhu, Y.J., Starost, M., Meltzer, P., Sood, R., Liu, P., Cheng, S.Y. (2020) Generation of novel genetic models to dissect resistance to thyroid hormone receptor alpha in zebrafish. Thyroid : official journal of the American Thyroid Association. 30(2):314-328
- Han, C.R., Wang, H., Hoffmann, V., Zerfas, P., Kruhlak, M., Cheng, S.Y. (2020) Thyroid hormone receptor α mutations cause heart defects in zebrafish. Thyroid : official journal of the American Thyroid Association. 31(2):315-326
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