Gene
pcsk5a
- ID
- ZDB-GENE-060531-130
- Name
- proprotein convertase subtilisin/kexin type 5a
- Symbol
- pcsk5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within anterior lateral line development and neuromast development. Predicted to be located in membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including eye; lateral line system; liver; otic vesicle; and pleuroperitoneal region. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chitramuthu et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa397 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8843 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9667 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14669 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20536 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33720 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38507 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pcsk5a | N/A | Chitramuthu et al., 2010 |
| MO2-pcsk5a | N/A | Chitramuthu et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023827 | Peptidase S8, subtilisin, Asp-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Furin-like repeat | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Kexin/furin catalytic domain | P domain | Peptidase S8, pro-domain | Peptidase S8, pro-domain superfamily | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, Asp-active site | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site | TNFR/NGFR cysteine-rich region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q4U3 | InterPro | 1867 | ||||||||||||||||
| UniProtKB:A0A8M1RIN1 | InterPro | 1867 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcsk5a-201
(1)
|
Ensembl | 5,466 nt | ||
| mRNA |
pcsk5a-202
(1)
|
Ensembl | 3,495 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-267I17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077582 (1) | 3495 nt | ||
| Genomic | GenBank:CR383678 (1) | 198392 nt | ||
| Polypeptide | UniProtKB:A0A8M1RIN1 (1) | 1867 aa |
- Klaver, E.J., Dukes-Rimsky, L., Kumar, B., Xia, Z.J., Dang, T., Lehrman, M.A., Angel, P., Drake, R.R., Freeze, H.H., Steet, R., Flanagan-Steet, H. (2021) Protease-dependent defects in N-cadherin processing drive PMM2-CDG pathogenesis. JCI insight. 6(24):
- Li, X.D., Tu, H.W., Hu, K.Q., Liu, Y.G., Mao, L.N., Wang, F.Y., Qu, H.Y., Chen, Q. (2021) Effects of Toluene on the Development of the Inner Ear and Lateral Line Sensory System of Zebrafish. Biomedical and environmental sciences : BES. 34:110-118
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Erickson, T., Nicolson, T. (2015) Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish. BMC Genomics. 16:842
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Ojanen, M.J., Turpeinen, H., Cordova, Z.M., Hammarén, M.M., Harjula, S.K., Parikka, M., Rämet, M., Pesu, M. (2015) The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum. Infection and Immunity. 83(4):1431-42
- Chitramuthu, B.P., and Bennett, H.P. (2013) High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function. Journal of visualized experiments : JoVE. (80):e50644
- Turpeinen, H., Oksanen, A., Kivinen, V., Kukkurainen, S., Uusimaki, A., Ramet, M., Parikka, M., Hytonen, V.P., Nykter, M., and Pesu, M. (2013) Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a). The Journal of biological chemistry. 288(51):36610-23
- Chitramuthu, B.P., Baranowski, D.C., Cadieux, B., Rousselet, E., Seidah, N.G., and Bennett, H.P. (2010) Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: Functional assessment during lateral line development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(11):2933-2946
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