Gene
npepps
- ID
- ZDB-GENE-060524-3
- Name
- aminopeptidase puromycin sensitive
- Symbol
- npepps Nomenclature History
- Previous Names
-
- psa
- fb68d07
- sb:cb848
- sb:eu910
- wu:fb68d07
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables aminopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in nervous system; pectoral fin musculature; and proliferative region. Orthologous to human NPEPPS (aminopeptidase puromycin sensitive).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb848 (6 images)
- eu910 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35043 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014782 | Peptidase M1, membrane alanine aminopeptidase |
| Domain | IPR024571 | ERAP1-like C-terminal domain |
| Domain | IPR045357 | Aminopeptidase N-like , N-terminal domain |
| Family | IPR001930 | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase |
| Family | IPR034016 | Aminopeptidase N-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminopeptidase N-like , N-terminal domain | Aminopeptidase N-like , N-terminal domain superfamliy | Aminopeptidase N-type | ERAP1-like C-terminal domain | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase | Peptidase M1 family aminopeptidases | Peptidase M1, membrane alanine aminopeptidase | Peptidase M4/M1, CTD superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NSE3 | InterPro | 872 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
npepps-201
(1)
|
Ensembl | 4,426 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-156L18 | ZFIN Curated Data | |
| Encodes | EST | cb848 | Thisse et al., 2001 | |
| Encodes | EST | eu910 | Thisse et al., 2005 | |
| Has Artifact | EST | fb68d07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001164027 (1) | 4642 nt | ||
| Genomic | GenBank:BX469912 (1) | 156480 nt | ||
| Polypeptide | UniProtKB:A0A8M1NSE3 (1) | 872 aa |
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Chen, S.H., Cao, M.J., Huang, J.Z., and Wu, G.P. (2011) Identification of a puromycin-sensitive aminopeptidase from zebrafish (Danio rerio). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 159(1):10-7
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