Gene
edem2
- ID
- ZDB-GENE-060519-1
- Name
- ER degradation enhancer, mannosidase alpha-like 2
- Symbol
- edem2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to act upstream of or within carbohydrate metabolic process; endoplasmic reticulum mannose trimming; and mannose trimming involved in glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1793 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15242 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37613 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45786 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ER degradation-enhancing alpha-mannosidase-like protein 1/2/3 | Glycoside hydrolase family 47 | Seven-hairpin glycosidases | Six-hairpin glycosidase-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IAP0 | InterPro | 560 | ||||
| UniProtKB:A0A8M9PKN4 | InterPro | 427 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-232F3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001305614 (1) | 1928 nt | ||
| Genomic | GenBank:CU681838 (2) | 41048 nt | ||
| Polypeptide | UniProtKB:A0A0R4IAP0 (1) | 560 aa |
- Fung, C., Wilding, B., Schittenhelm, R.B., Bryson-Richardson, R.J., Bird, P.I. (2023) Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish. International Journal of Molecular Sciences. 24(3):
- Sæle, Ø., Rød, K.E.L., Quinlivan, V.H., Li, S., Farber, S.A. (2018) A novel system to quantify intestinal lipid digestion and transport. Biochimica et biophysica acta. 1863(9):948-957
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nachtigall, P., Dias, M., Pinhal, D. (2014) Evolution and genomic organization of muscle microRNAs in fish genomes. BMC Evolutionary Biology. 14:196
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