Gene

brca2

ID
ZDB-GENE-060510-3
Name
BRCA2 DNA repair associated
Symbol
brca2 Nomenclature History
Previous Names
  • fancd1 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Involved in animal organ development; sex determination; and spermatogenesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain cancer (multiple); hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Is expressed in gonad; heart; intermediate cell mass of mesoderm; intermediate mesoderm; and nervous system. Orthologous to human BRCA2 (BRCA2 DNA repair associated).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brca2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, male, susceptibility to} 114480
Fanconi anemia complementation group D1 Alliance Fanconi anemia, complementation group D1 605724
medulloblastoma Alliance {Medulloblastoma} 155255
nephroblastoma Alliance Wilms tumor 194070
prostate cancer Alliance {Prostate cancer} 176807
{Breast-ovarian cancer, familial, 2} 612555
{Glioblastoma 3} 613029
{Pancreatic cancer 2} 613347
Associated With brca2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015187 BRCA2, OB1
Domain IPR015188 BRCA2, OB3
Domain IPR015205 Tower domain
Domain IPR015252 Breast cancer type 2 susceptibility protein, helical domain
Family IPR015525 Breast cancer type 2 susceptibility protein
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR036315 BRCA2 helical domain superfamily
Repeat IPR002093 BRCA2 repeat
Domain Details Per Protein
Protein Length BRCA2 helical domain superfamily BRCA2, OB1 BRCA2, OB3 BRCA2 repeat Breast cancer type 2 susceptibility protein Breast cancer type 2 susceptibility protein, helical domain Nucleic acid-binding, OB-fold Tower domain
UniProtKB:A8QLH9 2874
UniProtKB:F1R8E8 2874
UniProtKB:B7ZVU5 2874
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations