Gene

stim1a

ID

ZDB-GENE-060503-914

Name

stromal interaction molecule 1a

Symbol

stim1a Nomenclature History

Previous Names

si:dkey-24p1.5

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have calcium channel regulator activity and calcium ion binding activity. Predicted to be involved in activation of store-operated calcium channel activity; cellular calcium ion homeostasis; and store-operated calcium entry. Predicted to localize to endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in Stormorken syndrome; primary immunodeficiency disease; and tubular aggregate myopathy. Orthologous to human STIM1 (stromal interaction molecule 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stim1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 10	Alliance	Immunodeficiency 10	612783
Stormorken syndrome	Alliance	Stormorken syndrome	185070
tubular aggregate myopathy 1	Alliance	Myopathy, tubular aggregate, 1	160565

Associated With stim1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032393	Stromal interaction molecule, Orai1-activating region
Domain	IPR037609	Stromal interaction molecule 1, SAM domain
Family	IPR037608	Stromal interaction molecule
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily

Domain Details Per Protein

Protein	Length	Sterile alpha motif/pointed domain superfamily	Stromal interaction molecule	Stromal interaction molecule 1, SAM domain	Stromal interaction molecule, Orai1-activating region
UniProtKB:Q1LY88 InterPro	676
UniProtKB:A0A8M2BKR0 InterPro	781
UniProtKB:A0A8M2BKP3 InterPro	808
UniProtKB:A0A2R8RIM0 InterPro	703

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	stim1a-201 (1) Ensembl	Ensembl	4,416 nt	Select Tool
mRNA	stim1a-202 (1) Ensembl	Ensembl	7,520 nt	Select Tool ZFIN BLAST
mRNA	stim1a-203 (1) Ensembl	Ensembl	2,109 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations