Gene
stim1a
- ID
- ZDB-GENE-060503-914
- Name
- stromal interaction molecule 1a
- Symbol
- stim1a Nomenclature History
- Previous Names
-
- si:dkey-24p1.5
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel regulator activity and calcium ion binding activity. Acts upstream of with a positive effect on axon extension involved in axon guidance. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027645Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35971 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| xt16 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 10 | Alliance | Immunodeficiency 10 | 612783 |
| Stormorken syndrome | Alliance | Stormorken syndrome | 185070 |
| tubular aggregate myopathy 1 | Alliance | Myopathy, tubular aggregate, 1 | 160565 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sterile alpha motif/pointed domain superfamily | Stromal interaction molecule | Stromal interaction molecule 1, SAM domain | Stromal interaction molecule, Orai1-activating region |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LY88 | InterPro | 676 | ||||
| UniProtKB:A0A8M2BKR0 | InterPro | 781 | ||||
| UniProtKB:A0A8M2BKP3 | InterPro | 808 | ||||
| UniProtKB:A0A2R8RIM0 | InterPro | 703 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stim1a-201
(1)
|
Ensembl | 4,416 nt | ||
| mRNA |
stim1a-202
(1)
|
Ensembl | 7,520 nt | ||
| mRNA |
stim1a-203
(1)
|
Ensembl | 2,109 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24P1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162007 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044799 (1) | 2934 nt | ||
| Genomic | GenBank:BX072550 (1) | 229061 nt | ||
| Polypeptide | UniProtKB:A0A8M2BKP3 (1) | 808 aa |
- Xin, Y., Guan, J., Li, Y., Duan, C. (2021) Regulation of cell quiescence-proliferation balance by Ca2+-CaMKK-Akt signaling. Journal of Cell Science. 134(20):
- Gupta, R.K., Wasilewska, I., Palchevska, O., Kuźnicki, J. (2020) Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. International Journal of Molecular Sciences. 21(17):
- Wasilewska, I., Gupta, R.K., Wojtaś, B., Palchevska, O., Kuźnicki, J. (2020) stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae. Cells. 9(5):
- Pavez, M., Thompson, A.C., Arnott, H.J., Mitchell, C.B., D'Atri, I., Don, E.K., Chilton, J.K., Scott, E.K., Lin, J.Y., Young, K.M., Gasperini, R.J., Foa, L. (2019) STIM1 is required for remodelling of the endoplasmic reticulum and microtubule cytoskeleton in steering growth cones. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(26):5095-5114
- Wasilewska, I., Gupta, R.K., Palchevska, O., Kuźnicki, J. (2019) Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Genes. 10(3)
- Motiani, R.K., Tanwar, J., Raja, D.A., Vashisht, A., Khanna, S., Sharma, S., Srivastava, S., Sivasubbu, S., Natarajan, V.T., Gokhale, R.S. (2018) STIM1 activation of adenylyl cyclase 6 connects Ca2+ and cAMP signaling during melanogenesis.. The EMBO journal. 37(5)
- Tse, M.K., Hung, T.S., Chan, C.M., Wong, T., Dorothea, M., Leclerc, C., Moreau, M., Miller, A.L., Webb, S.E. (2018) Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres.. Science China. Life sciences. 61(11):1352-1368
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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