Gene
acss3
- ID
- ZDB-GENE-060503-816
- Name
- acyl-CoA synthetase short chain family member 3
- Symbol
- acss3 Nomenclature History
- Previous Names
-
- si:dkey-231a18.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable propionate-CoA ligase activity. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ACSS3 (acyl-CoA synthetase short chain family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010108Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la010657Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015367Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020845 | AMP-binding, conserved site |
| Domain | IPR000873 | AMP-dependent synthetase/ligase domain |
| Domain | IPR025110 | AMP-binding enzyme, C-terminal domain |
| Domain | IPR032387 | Acetyl-coenzyme A synthetase, N-terminal domain |
| Homologous_superfamily | IPR042099 | ANL, N-terminal domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acetyl-coenzyme A synthetase, N-terminal domain | AMP-binding, conserved site | AMP-binding enzyme, C-terminal domain | AMP-binding enzyme, C-terminal domain superfamily | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TBI0 | InterPro | 714 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-231A18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_689284 (1) | |||
| Genomic | GenBank:BX537308 (1) | 191880 nt | ||
| Polypeptide | UniProtKB:A0A8N7TBI0 (1) | 714 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Watkins, P.A., Maiguel, D., Jia, Z., and Pevsner, J. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Journal of Lipid Research. 48(12):2736-2750
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