Gene

loxl1

ID
ZDB-GENE-060503-693
Name
lysyl oxidase-like 1
Symbol
loxl1 Nomenclature History
Previous Names
  • si:ch211-238c15.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable protein-lysine 6-oxidase activity. Acts upstream of or within notochord development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in hypochord and notochord. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; and primary open angle glaucoma. Orthologous to human LOXL1 (lysyl oxidase like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Gansner et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With loxl1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
exfoliation syndrome Alliance {Exfoliation syndrome, susceptibility to} 177650
1 - 1 of 1
Associated With loxl1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019828 Lysyl oxidase, conserved site
Family IPR001695 Lysyl oxidase
Family IPR050912 Lysyl oxidase-like protein
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Lysyl oxidase Lysyl oxidase, conserved site Lysyl oxidase-like protein
UniProtKB:Q2PS19 InterPro 526
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA loxl1-201 (1) Ensembl 6,757 nt
mRNA loxl1-202 (1) Ensembl 1,737 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations