Gene
loxl1
- ID
- ZDB-GENE-060503-693
- Name
- lysyl oxidase-like 1
- Symbol
- loxl1 Nomenclature History
- Previous Names
-
- si:ch211-238c15.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable protein-lysine 6-oxidase activity. Acts upstream of or within notochord development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in hypochord and notochord. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; and primary open angle glaucoma. Orthologous to human LOXL1 (lysyl oxidase like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gansner et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| exfoliation syndrome | Alliance | {Exfoliation syndrome, susceptibility to} | 177650 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Lysyl oxidase | Lysyl oxidase, conserved site | Lysyl oxidase-like protein |
|---|---|---|---|---|---|
| UniProtKB:Q2PS19 | InterPro | 526 |
Interactions and Pathways
No data available
Plasmids
No data available