Gene
kdm4b
- ID
- ZDB-GENE-060503-664
- Name
- lysine (K)-specific demethylase 4B
- Symbol
- kdm4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K9 demethylase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Is expressed in caudal hematopoietic tissue. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Orthologous to human KDM4B (lysine demethylase 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yu et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, autosomal dominant 65 | 619320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR002999 | Tudor domain |
| Domain | IPR003347 | JmjC domain |
| Domain | IPR003349 | JmjN domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR034732 | Extended PHD (ePHD) domain |
| Domain | IPR040477 | Lysine-specific demethylase 4-like, Tudor domain |
| Domain | IPR047483 | Lysine-specific demethylase 4B, first Tudor domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Length | Extended PHD (ePHD) domain | JmjC domain | JmjN domain | Lysine-specific demethylase 4B, first Tudor domain | Lysine-specific demethylase 4-like, Tudor domain | Tudor domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LUQ0
|
1134 | ||||||||||
|
UniProtKB:A0A8M9P494
|
1132 |
Interactions and Pathways
No data available
Plasmids
No data available