ZFIN ID: ZDB-GENE-060503-539
Gene Name: natriuretic peptide receptor 1a
Gene Symbol: npr1a    Nomenclature History

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Previous Name: si:dkey-27c15.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Involved in axon guidance and cardiac muscle cell proliferation. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; essential hypertension; and myocardial infarction. Is expressed in several structures, including brain; eye; heart; integument; and kidney. Orthologous to several human genes including NPR1 (natriuretic peptide receptor 1).
Genome Resources: Alliance (1),  Gene:560653 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10670 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15690 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29215 Point Mutation Unknown Premature Stop ENU
    sa39249 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44916 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH npr1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH npr1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA npr1a-201 (1)    Ensembl 5171
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM npr1a No data available
    MARKER RELATIONSHIPS
    npr1a Contained in: [BAC] CH73-85D12 (1), DKEY-27C15 (1) (order this), DKEY-32I12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044937 (1) 3204 nt
    Genomic GenBank:BX465837 (1) 206154 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LX84 (1) 1067 aa
    Sequence Information (all 17)
    ORTHOLOGY for npr1a ( Chr: 19 )
    CITATIONS (20)