Gene

ptprfb

ID

ZDB-GENE-060503-530

Name

protein tyrosine phosphatase receptor type Fb

Symbol

ptprfb Nomenclature History

Previous Names

lar (1)
fj23e12
si:dkey-21k10.1
wu:fj23e12 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have protein tyrosine phosphatase activity. Involved in sensory neuron axon guidance. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in hyperinsulinism. Is expressed in liver and nervous system. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptprfb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Breasts and/or nipples, aplasia or hypoplasia of, 2	616001

Associated With ptprfb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR050713	Receptor-type Tyrosine-protein Phosphatases/Ushers
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase, catalytic	Protein-tyrosine phosphatase-like	Receptor-type Tyrosine-protein Phosphatases/Ushers	Tyrosine-specific protein phosphatase, PTPase domain	Tyrosine-specific protein phosphatases domain
UniProtKB:A0A8M3APM3 InterPro	1904
UniProtKB:A0A8M3B069 InterPro	1918
UniProtKB:A0A8M3AQ61 InterPro	1825
UniProtKB:A0A8M9QC31 InterPro	1807
UniProtKB:A0A8M3B7N0 InterPro	1900
UniProtKB:A0A8M3B074 InterPro	1802
UniProtKB:A0A8M3B7M8 InterPro	1921
UniProtKB:A0A2R8QDC8 InterPro	1913
UniProtKB:A0A8M3AQ53 InterPro	1927
UniProtKB:A0A8M3AQ56 InterPro	1919
UniProtKB:A0A8M3AX63 InterPro	1923
UniProtKB:A0A8M9Q0G3 InterPro	1817
UniProtKB:A0A8M3APL8 InterPro	1923
UniProtKB:A0A8M9QPW8 InterPro	1798
UniProtKB:A4IFW2 InterPro	1909
UniProtKB:A0A8M9QH96 InterPro	1917
UniProtKB:A0A8M9QLG3 InterPro	1813
UniProtKB:A0A8M9QC27 InterPro	1811

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptprfb-201 (1) Ensembl	Ensembl	7,679 nt	Select Tool
mRNA	ptprfb-202 (1) Ensembl	Ensembl	442 nt	Select Tool
mRNA	ptprfb-204 (1) Ensembl	Ensembl	7,327 nt	Select Tool ZFIN BLAST
mRNA	ptprfb-205 (1) Ensembl	Ensembl	7,957 nt	Select Tool ZFIN BLAST
mRNA	ptprfb-206 (1) Ensembl	Ensembl	7,978 nt	Select Tool ZFIN BLAST
mRNA	ptprfb-207 (1) Ensembl	Ensembl	7,984 nt	Select Tool ZFIN BLAST
mRNA	ptprfb-208 (1) Ensembl	Ensembl	7,633 nt	Select Tool ZFIN BLAST
ncRNA	ptprfb-003 (1) Ensembl	Ensembl	524 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:37111

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations