Gene
tm6sf2b
- ID
- ZDB-GENE-060503-338
- Name
- transmembrane 6 superfamily member 2b
- Symbol
- tm6sf2b Nomenclature History
- Previous Names
-
- tm6sf2
- si:dkey-19f23.3
- zgc:158825
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within lipid homeostasis and regulation of response to endoplasmic reticulum stress. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in intestine; liver; and posterior intestine. Used to study fatty liver disease. Orthologous to several human genes including TM6SF2 (transmembrane 6 superfamily member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Hare et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from O'Hare et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | WT + MO1-tm6sf2b | standard conditions | O'Hare et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EXPERA domain | Transmembrane 6 superfamily member 1/2 |
|---|---|---|---|
|
UniProtKB:A1L2E0
|
374 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tm6sf2-202
(1)
|
Ensembl | 1,283 nt | ||
| mRNA |
tm6sf2-203
(1)
|
Ensembl | 5,595 nt | ||
| ncRNA |
tm6sf2-002
(1)
|
Ensembl | 852 nt |
Interactions and Pathways
No data available
Plasmids
No data available