ZFIN ID: ZDB-FISH-180912-16
Fish name: WT + MO1-tm6sf2b
Genotype: WT
Targeting Reagent: MO1-tm6sf2b
HUMAN DISEASE MODELED by WT + MO1-tm6sf2b
Human Disease Conditions Citations
fatty liver disease standard conditions O'Hare et al., 2017
GENE EXPRESSION
Gene expression in WT + MO1-tm6sf2b
Protein expression No data available
Reporter gene expression No data available
PHENOTYPE
Phenotype in WT + MO1-tm6sf2b
Phenotype Conditions Figures
enterocyte endoplasmic reticulum lumen increased width, abnormal standard conditions Fig. 6 from O'Hare et al., 2017
enterocyte lipid droplet increased amount, abnormal standard conditions Fig. 6 from O'Hare et al., 2017
enterocyte lipid droplet increased amount, abnormal high fat Fig. 7 from O'Hare et al., 2017
intestine fatty, abnormal standard conditions Fig. 6 from O'Hare et al., 2017
intestine lipid homeostasis disrupted, abnormal high fat Fig. 7 from O'Hare et al., 2017
liver fatty, abnormal standard conditions Fig. 2Fig. 5Fig. S3 from O'Hare et al., 2017
liver xbp1 expression increased amount, abnormal standard conditions Fig. 3 from O'Hare et al., 2017
liver hspa5 expression increased amount, abnormal standard conditions Fig. 3 from O'Hare et al., 2017
liver ddit3 expression increased amount, abnormal standard conditions Fig. 3 from O'Hare et al., 2017
liver edem1 expression increased amount, abnormal standard conditions Fig. 3 from O'Hare et al., 2017
liver endoplasmic reticulum lumen dilated, abnormal standard conditions Fig. S6 from O'Hare et al., 2017
liver endoplasmic reticulum lumen increased width, abnormal standard conditions Fig. S6 from O'Hare et al., 2017
liver lipid droplet increased amount, abnormal standard conditions Fig. 2Fig. 3Fig. 5 from O'Hare et al., 2017
whole organism edem1 expression increased amount, abnormal standard conditions Fig. 5 from O'Hare et al., 2017
whole organism ddit3 expression increased amount, abnormal standard conditions Fig. 5 from O'Hare et al., 2017
whole organism hspa5 expression increased amount, abnormal standard conditions Fig. 5 from O'Hare et al., 2017
whole organism xbp1 expression increased amount, abnormal standard conditions Fig. 5 from O'Hare et al., 2017
whole organism low-density lipoprotein particle decreased amount, abnormal standard conditions Fig. 2 from O'Hare et al., 2017

CITATIONS  (1)