ZFIN is now using GRCz12tu for Genomic Data
Gene
wdr62
- ID
- ZDB-GENE-060503-291
- Name
- WD repeat domain 62
- Symbol
- wdr62 Nomenclature History
- Previous Names
-
- fa11h05
- fb33e12
- si:ch211-152c12.2
- wu:fa11h05
- wu:fb33e12
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in regulation of mitotic cell cycle. Predicted to be active in mitotic spindle. Used to study microcephaly. Human ortholog(s) of this gene implicated in autosomal recessive primary microcephaly; intellectual disability; polymicrogyria; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 2 with or without cortical malformations | Alliance | Microcephaly 2, primary, autosomal recessive, with or without cortical malformations | 604317 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| microcephaly | WT + MO1-wdr62 | standard conditions | Novorol et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR056161 | MABP1/WDR62, first WD40 domain |
| Domain | IPR056162 | MABP1/WDR62, second WD40 domain |
| Family | IPR055292 | Mitogen-activated protein kinase-binding protein 1 |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | MABP1/WDR62, first WD40 domain | MABP1/WDR62, second WD40 domain | Mitogen-activated protein kinase-binding protein 1 | Quinoprotein alcohol dehydrogenase-like superfamily | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NPK9 | InterPro | 1493 | |||||||
| UniProtKB:A0A8M2BH37 | InterPro | 1492 | |||||||
| UniProtKB:A0A286YBK5 | InterPro | 1519 | |||||||
| UniProtKB:A0A8M2BGZ4 | InterPro | 1518 | |||||||
| UniProtKB:A0AC58HBE6 | InterPro | 1494 | |||||||
| UniProtKB:A0AC58HBE9 | InterPro | 1519 | |||||||
| UniProtKB:A0ACD6B7S6 | InterPro | 1520 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers