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Gene

wdr62

ID
ZDB-GENE-060503-291
Name
WD repeat domain 62
Symbol
wdr62 Nomenclature History
Previous Names
  • fa11h05
  • fb33e12
  • si:ch211-152c12.2
  • wu:fa11h05
  • wu:fb33e12
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Used to study microcephaly. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Novorol et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wdr62 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary autosomal recessive microcephaly 2 with or without cortical malformations Alliance Microcephaly 2, primary, autosomal recessive, with or without cortical malformations 604317
Associated With wdr62 Via Experimental Models
Human Disease Fish Conditions Citations
microcephaly WT + MO1-wdr62 standard conditions Novorol et al., 2013
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017986 WD40-repeat-containing domain
Domain IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
Homologous_superfamily IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Domain Details Per Protein
Protein Length Anaphase-promoting complex subunit 4, WD40 domain Quinoprotein alcohol dehydrogenase-like superfamily WD40 repeat WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A286YBK5 1519
UniProtKB:B3DJP8 891
UniProtKB:F6NPK9 1493
UniProtKB:Q1L932 252
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations